Plasma miR-26a-5p is a biomarker for retinal neurodegeneration of early diabetic retinopathy.

ABSTRACT:

Purpose

Retinal neurodegeneration is an early pathological change in diabetic retinopathy (DR). Early-stage retinal neurodegeneration is usually asymptomatic. This study aims to identify circulating microRNAs (miRNAs) as sensitive biomarkers for early retinal neurodegeneration.

Methods

We profiled the plasma miRNA expression in three mild nonproliferative diabetic retinopathy (NPDR) cases and three matched non-DR patients using RNA sequencing. The differential miRNAs were validated with qRT-PCR. The retinal nerve fibre layer (RNFL) thickness of the eyes was measured using spectral-domain Optical coherence tomography (SD-OCT). The association between differential miRNAs and RNFL thickness was analysed using the Pearson correlation analysis. Bioinformatics tools were used to p

SUBMITTER: Shi R 

PROVIDER: S-EPMC8169691 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature