A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma.

ABSTRACT: Ovarian cancer (OV) is a common type of carcinoma in females. Many studies have reported that ferroptosis is associated with the prognosis of OV patients. However, the mechanism by which this occurs is not well understood. We utilized Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) to identify ferroptosis-related genes in OV. In the present study, we applied Cox regression analysis to select hub genes and used the least absolute shrinkage and selection operator to construct a prognosis prediction model with mRNA expression profiles and clinical data from TCGA. A series of analyses for this signature was performed in TCGA. We then verified the identified signature using International Cancer Genome Consortium (ICGC) data. After a series of analyses, we identified six hub

SUBMITTER: Yu Z 

PROVIDER: S-EPMC8169824 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature