Ontology highlight
ABSTRACT:
SUBMITTER: Mossner S
PROVIDER: S-EPMC8169946 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Mossner Sofie S Floss Doreen Manuela DM Scheller Jürgen J
iScience 20210424 5
Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization is considered to be essential for receptor activation. Synthetic TNFR1, TNFR2, and Fas/CD95 receptors were activated by synthetic trimeric ligands which induced NF-κB signaling or Caspase-induced apoptosis. Albeit dimeric receptor activation did not induc ...[more]