Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma.

ABSTRACT:

Background

HCC is one of the most common malignancies with an increasing incidence worldwide, especially in Asian countries. However, even though targeted cancer therapy drugs such as sorafenib and regorafenib are available, the overall outcome of HCC remains unsatisfactory. Thus, it is urgent to investigate the molecular mechanisms of HCC progression, so as to provide accurate diagnostic criteria and therapeutic targets.

Methods

RNA-seq data was used to identify and quantify circular RNAs (circRNAs). DESeq2 was used to identify the differentially expressed circRNAs. miRNA binding sites within circRNAs were identified by miRanda. Gene set enrichment analysis (GSEA) was conducted to predict the biological function of circRNAs.

Results

The differential expression analys

SUBMITTER: Huang ZL 

PROVIDER: S-EPMC8170000 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature