Emerging Role of m⁶ A Methylome in Brain Development: Implications for Neurological Disorders and Potential Treatment.

ABSTRACT: Dynamic modification of RNA affords proximal regulation of gene expression triggered by non-genomic or environmental changes. One such epitranscriptomic alteration in RNA metabolism is the installation of a methyl group on adenosine [N⁶-methyladenosine (m⁶A)] known to be the most prevalent modified state of messenger RNA (mRNA) in the mammalian cell. The methylation machinery responsible for the dynamic deposition and recognition of m⁶A on mRNA is composed of subunits that play specific roles, including reading, writing, and erasing of m⁶A marks on mRNA to influence gene expression. As a result, peculiar cellular perturbations have been linked to dysregulation of components of the mRNA methylation machinery or its cofactors. It is increasingly cl

SUBMITTER: Sokpor G 

PROVIDER: S-EPMC8170044 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature