Project description:Root-secreted coumarins and the microbiota interact to improve iron nutrition in Arabidopsis. Harbort and Hashimoto et al. Cell Host & Microbe 2020
Project description:Here, we combined lineage tracing in a newly developed spontaneous metastatic mouse model of melanoma, advanced imaging and single-cell RNA-sequencing approaches to search for (patho) physiologically-relevant melanoma cellular states. We identified a population of reporter-positive melanoma cells located in intravascular niches of various metastatic organs. These intravascular metastatic cells were dormant, negative for characteristic melanoma markers and acquired endothelial cell markers.