High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue.

ABSTRACT: Diffuse optical imaging (DOI) provides in vivo quantification of tissue chromophores such as oxy- and deoxyhemoglobin (HbO2 and HHb, respectively). These parameters have been shown to be useful for predicting neoadjuvant treatment response in breast cancer patients. However, most DOI devices designed for the breast are nonportable, making frequent longitudinal monitoring during treatment a challenge. Furthermore, hemodynamics related to the respiratory cycle are currently unexplored in the breast and may have prognostic value. To design, fabricate, and validate a high optode-density wearable continuous wave diffuse optical probe for the monitoring of breathing hemodynamics in breast tissue. The probe has a rigid-flex design with 16 dual-wavelength sources and 16 detectors. Performance was

SUBMITTER: Spink S 

PROVIDER: S-EPMC8170390 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature