Dynamic posttranslational modifications of cytoskeletal proteins unveil hot spots under nitroxidative stress.

ABSTRACT: The cytoskeleton is a supramolecular structure consisting of interacting protein networks that support cell dynamics in essential processes such as migration and division, as well as in responses to stress. Fast cytoskeletal remodeling is achieved with the participation of regulatory proteins and posttranslational modifications (PTMs). Redox-related PTMs are emerging as critical players in cytoskeletal regulation. Here we used a cellular model of mild nitroxidative stress in which a peroxynitrite donor induced transient changes in the organization of three key cytoskeletal proteins, i.e., vimentin, actin and tubulin. Nitroxidative stress-induced reconfiguration of intermediate filaments, microtubules and actin structures were further correlated with their PTM profiles and dynamics of the P

SUBMITTER: Griesser E 

PROVIDER: S-EPMC8170420 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature