Relationship between clinical outcomes measures and personal and social performance functioning in a prospective, interventional study in schizophrenia.

ABSTRACT:

Objectives

To explore clinical and demographic characteristics impacting patient functioning by determining extent of overlap in factors driving change in Personal and Social Performance (PSP) and other clinical outcomes.

Methods

Post-hoc analysis from a single-arm trial of paliperidone extended release in adult patients with nonacute symptomatic schizophrenia. Psychosocial functioning measures: PSP, Clinical Global Impression-Severity (CGI-S), Positive and Negative Syndrome Scale (PANSS), Short-Form 36 (SF-36), treatment satisfaction, sleep quality/daytime drowsiness, and Extrapyramidal Symptoms Rating Scale.

Results

Highest correlations with PSP total score change included PANSS total score change (Spearman's r = 0.607), PANSS general psychopathology change (r = 0.5

SUBMITTER: Vauth R 

PROVIDER: S-EPMC8170566 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature