Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species.

ABSTRACT:

Background

Coxiella burnetii is the Gram-negative bacterium responsible for Q fever in humans and coxiellosis in domesticated agricultural animals. Previous vaccination efforts with whole cell inactivated bacteria or surface isolated proteins confer protection but can produce a reactogenic immune responses. Thereby a protective vaccine that does not cause aberrant immune reactions is required. The critical role of T-cell immunity in control of C. burnetii has been made clear, since either CD8⁺ or CD4⁺ T cells can empower clearance. The purpose of this study was to identify C. burnetii proteins bearing epitopes that interact with major histocompatibility complexes (MHC) from multiple host species (human, mouse, and cattle).

Results

Of the annotated 1815

SUBMITTER: Piel LMW 

PROVIDER: S-EPMC8170629 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature