Evaluating of Gene Expression Alteration after Garlic Consumption, Analyzing through Bioinformatics Approach.

ABSTRACT: Molecular study of garlic as a popular food ingredient could better understand its health benefits such as immunological effects. For this aim, effects of garlic on the spleen and possible side effects including oxidative stress increment, the molecular mechanism is investigated through network analysis of differentially expressed genes in the treatment of garlic. Protein-protein interaction (PPI) network analysis of spleen gene expression profile of Mus musculus (8-week old male C57BL/6J mice) in garlic treatments from a microarray study with the code of GSE10344 was analyzed via GEO2R software. Furthermore, Cytoscape V 3.7.1 was applied to construct and analyze a network of up- and down-regulated genes. The differentially expressed genes (DEGs) were analyzed via the CluePedia plug

SUBMITTER: Esmaeili S 

PROVIDER: S-EPMC8170752 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature