Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD).
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ABSTRACT:
SUBMITTER: Lv F
PROVIDER: S-EPMC8170805 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD).
Lv Fang F Wu Xueying X Song Jin J Wang Pan P Ren Shucheng S Guo Wei W Xue Qi Q Zhang Henghui H Zhao Jun J
Biomarker research 20210602 1
It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is cl ...[more]
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