LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p.

ABSTRACT:

Background

Long non-coding RNAs exert vital roles in several types of cancer. The objective of this study was to explore the role of LINC_00355 in gastric cancer (GC) progression and its potential mechanism.

Methods

The expression levels of LINC_00355 in GC tissues and cells were detected by quantitative real-time PCR, followed by assessing the effects of LINC_00355 knockdown or overexpression on cell properties. Dual-luciferase reporter assay was utilized to identify the relationship between LINC_00355 and microRNA (miR)-15a-5p and miR-15a-5p and PHD finger protein 19 (PHF19), followed by the rescue experiments.

Results

The results showed that LINC_00355 was highly expressed in GC tissues and cells compared with the corresponding control. LINC_00355 knockdown decreas

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8170819 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature