Failure to complete standard radiation therapy in glioblastoma patients: Patterns from a national database with implications for survival and therapeutic decision making in older glioblastoma patients.

ABSTRACT:

Introduction

It is estimated that 5%-10% of patients with newly diagnosed glioblastoma (GBM) fail to complete standard chemoradiation (CRT). We sought to determine the impact of failure to complete CRT on survival and to identify risk factors.

Methods

We queried the National Cancer Database and identified a cohort of 17,451 adults with GBM diagnosed from 2005 to 2012. The cohort was restricted to patients that started conventionally fractionated adjuvant chemoradiation of 1.8 to 2.0 Gy per fraction to a dose of ≤66Gy. Patients were stratified by RT dose: a) completed RT ≥ 58Gy, b) nearly completed RT ≥ 50Gy - <58Gy, and c) did not complete RT ≤ 50Gy.

Results

The CRT completion rate correlated with survival, 87% of patients completed CRT and had a median OS of 13.5 mon

SUBMITTER: Burton E 

PROVIDER: S-EPMC8170831 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature