Ontology highlight
ABSTRACT:
SUBMITTER: Alanbaei M
PROVIDER: S-EPMC8170900 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Alanbaei Muath M Abu-Farha Mohamed M Hebbar Prashantha P Melhem Motasem M Chandy Betty S BS Anoop Emil E Cherian Preethi P Al-Khairi Irina I Alkayal Fadi F Al-Mulla Fahd F Abubaker Jehad J Thanaraj Thangavel Alphonse TA
Genes 20210517 5
ANGPTL3 is an important regulator of lipid metabolism. Its inhibition in people with hypercholesteremia reduces plasma lipid levels dramatically. Genome-wide association studies have associated ANGPTL3 variants with lipid traits. Irisin, an exercise-modulated protein, has been associated with lipid metabolism. Intracellular accumulation of lipids impairs insulin action and contributes to metabolic disorders. In this study, we evaluate the impact of ANGPTL3 variants on levels of irisin and marker ...[more]