Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study.

ABSTRACT:

Background

There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity.

Methods

Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently pu

SUBMITTER: Xia J 

PROVIDER: S-EPMC8170931 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature