Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project.

ABSTRACT:

Background

Current interstitial lung disease (ILD) diagnostic guidelines assess criteria across clinical, radiologic and pathologic domains. Significant interobserver variation in histopathologic evaluation has previously been shown but the specific source of these discrepancies is poorly documented. We sought to document specific areas of difficulty and develop improved criteria that would reduce overall interobserver variation.

Methods

Using an internet-based approach, we reviewed selected images of specific diagnostic features of ILD histopathology and whole slide images of fibrotic ILD. After an initial round of review, we confirmed the presence of interobserver variation among our group. We then developed refined criteria and reviewed a second set of cases.

Results</

SUBMITTER: Camp R 

PROVIDER: S-EPMC8170950 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature