NoRCE: non-coding RNA sets cis enrichment tool.

ABSTRACT:

Background

While some non-coding RNAs (ncRNAs) are assigned critical regulatory roles, most remain functionally uncharacterized. This presents a challenge whenever an interesting set of ncRNAs needs to be analyzed in a functional context. Transcripts located close-by on the genome are often regulated together. This genomic proximity on the sequence can hint at a functional association.

Results

We present a tool, NoRCE, that performs cis enrichment analysis for a given set of ncRNAs. Enrichment is carried out using the functional annotations of the coding genes located proximal to the input ncRNAs. Other biologically relevant information such as topologically associating domain (TAD) boundaries, co-expression patterns, and miRNA target prediction information can be incorporat

SUBMITTER: Olgun G 

PROVIDER: S-EPMC8170991 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature