Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening.

ABSTRACT:

Background

Establishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an independent risk factor of early assessment of atherosclerotic risk.

Methods

We propose a non-invasive skin cholesterol detection method based on absorption spectroscopy. Detection reagents specifically bind to skin cholesterol and react with indicator to produce colored products, the skin cholesterol content can be obtained through absorption spectrum information on colored products detected by non-invasive technology. Gas chromatography is used to measure cholesterol extracted from the skin to verify the accuracy and reliability of the non-invasive test method.

SUBMITTER: Ni J 

PROVIDER: S-EPMC8170999 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature