Engineering a multi epitope vaccine against SARS-CoV-2 by exploiting its non structural and structural proteins.

ABSTRACT: SARS-CoV-2, the causative agent behind the ongoing pandemic exhibits an enhanced potential for infection when compared to its related family members- the SARS-CoV and MERS-CoV; which have caused similar disease outbreaks in the past. The severity of the global health burden, increasing mortality rate and the emergent economic crisis urgently demands the development of next generation vaccines. Amongst such emergent next generation vaccines are the multi-epitope subunit vaccines, which hold promise in combating deadly pathogens. In this study we have exploited immunoinformatics applications to delineate a vaccine candidate possessing multiple B and T cells epitopes by utilizing the SARS-CoV-2 non structural and structural proteins. The antigenicity potential, safety, structural stability an

SUBMITTER: Rajput VS 

PROVIDER: S-EPMC8171004 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature