Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replication.

ABSTRACT: The COVID-19 pandemic infection has claimed many lives and added to the social, economic, and psychological distress. The contagious disease has quickly spread to almost 218 countries and territories following the regional outbreak in China. As the number of infected populations increases exponentially, there is a pressing demand for anti-COVID drugs and vaccines. Virtual screening provides possible leads while extensively cutting down the time and resources required for ab-initio drug design. We report structure-based virtual screening of a hundred plus library of quinoline drugs with established antiviral, antimalarial, antibiotic or kinase inhibitor activity. In this study, targets having a role in viral entry, viral assembly, and viral replication have been selected. The targets includ

SUBMITTER: Anju A 

PROVIDER: S-EPMC8171009 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature