Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders.

ABSTRACT:

Background

Observational studies have identified various associations between neuroimaging alterations and neuropsychiatric disorders. However, whether such associations could truly reflect causal relations remains still unknown.

Results

Here, we leveraged genome-wide association studies (GWAS) summary statistics for (1) 11 psychiatric disorders (sample sizes varied from n = 9,725 to 1,331,010); (2) 110 diffusion tensor imaging (DTI) measurement (sample size n = 17,706); (3) 101 region-of-interest (ROI) volumes, and investigate the causal relationship between brain structures and neuropsychiatric disorders by two-sample Mendelian randomization. Among all DTI-Disorder combinations, we observed a significant causal association between the superior longitudinal fasciculus (SLF)

SUBMITTER: Song W 

PROVIDER: S-EPMC8171058 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature