Improving the sensitivity of T ₁ contrast-enhanced MRI and sensitive diagnosing tumors with ultralow doses of MnO octahedrons.

ABSTRACT: Rationale: Sensitive and accurate imaging of cancer is essential for early diagnosis and appropriate treatment. For generally employed magnetic resonance imaging (MRI) in clinic, comprehending how to enhance the contrast effect of T ₁ imaging is crucial for improving the sensitivity of cancer diagnosis. However, there is no study ever to reveal the clear mechanism of how to enhance the effect of T ₁ imaging and accurate relationships of influencing factors. Herein, this study aims to figure out key factors that affect the sensitivity of T ₁ contrast-enhanced MRI (CE-MRI), thereby to realize sensitive detection of tumors with low dose of CAs. Methods: Manganese oxide (MnO) nanoparticles (NPs) with various sizes and shapes w

SUBMITTER: Yang L 

PROVIDER: S-EPMC8171088 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature