Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study.
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ABSTRACT:
SUBMITTER: Chaney AM
PROVIDER: S-EPMC8171096 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study.
Chaney Aisling M AM Lopez-Picon Francisco R FR Serrière Sophie S Wang Rui R Bochicchio Daniela D Webb Samuel D SD Vandesquille Matthias M Harte Michael K MK Georgiadou Christina C Lawrence Catherine C Busson Julie J Vercouillie Johnny J Tauber Clovis C Buron Frédéric F Routier Sylvain S Reekie Tristan T Snellman Anniina A Kassiou Michael M Rokka Johanna J Davies Karen E KE Rinne Juha O JO Salih Dervis A DA Edwards Frances A FA Orton Llwyd D LD Williams Stephen R SR Chalon Sylvie S Boutin Hervé H
Theranostics 20210503 14
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss, necessitating the development of new AD models. The transgenic (TG) TgF344-AD rat has been reported to develop age-dependent AD features including neuronal loss and neurofibrillary tangles, despite only expressing <i>APP</i> and <i>PSEN1</i> mutations, suggesting an improved modelling of AD hallmarks. Alterations in neuronal networ ...[more]
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