The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease.

ABSTRACT: Viral proteases are highly specific and recognize conserved cleavage site sequences of ∼6-8 amino acids. Short stretches of homologous host-pathogen sequences (SSHHPS) can be found spanning the viral protease cleavage sites. We hypothesized that these sequences corresponded to specific host protein targets since >40 host proteins have been shown to be cleaved by Group IV viral proteases and one Group VI viral protease. Using PHI-BLAST and the viral protease cleavage site sequences, we searched the human proteome for host targets and analyzed the hit results. Although the polyprotein and host proteins related to the suppression of the innate immune responses may be the primary targets of these viral proteases, we identified other cleavable host proteins. These proteins appear to be related

SUBMITTER: Reynolds ND 

PROVIDER: S-EPMC8171221 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature