Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects.

ABSTRACT: Systematic investigations were performed with various substituted groups at C8 purine and ribose. A series of isoG analogs, C8-phenyl substituted isoG were synthesized and applied for Cs⁺ coordination. The structural proximity between purine and ribose limited pentaplex formation for C8-phenyl substituted isoG derivatives. Based on this observation, deoxy isoG derivative with modification on ribose (tert-butyldimethylsilyl ether) was applied to assemble with the Cs⁺ cation. Critical solvent (CDCl₃ and CD₃CN) and anion (BPh₄ ^-, BARF^-, and PF₆ ^-) effects were revealed, leading to the controllable formation of various stable isoG pentaplexes, including singly charged decamer, doubly charg

SUBMITTER: Liu M 

PROVIDER: S-EPMC8171338 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature