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High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies.

ABSTRACT: Clinical features of Kawasaki disease (KD) display overlap with common pediatric viral illnesses, leading some to hypothesize that a viral infection is the inciting event for KD. To investigate viral infection history in KD patients, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitation sequencing assay covering the complete reference protein sequences of known viruses with human tropism. KD and matched febrile control sera did not demonstrate differences in antiviral antibody profiles. We conclude that in the acute and subacute phases of disease, KD patients do not exhibit serologic evidence of exposure to known viruses that differs from controls.

SUBMITTER: Quiat D

PROVIDER: S-EPMC8171798 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies.

Quiat Daniel D Kula Tomasz T Shimizu Chisato C Kanegaye John T JT Tremoulet Adriana H AH Pitkowsky Zachary Z Son MaryBeth M Newburger Jane W JW Elledge Stephen J SJ Burns Jane C JC

The Journal of infectious diseases 20201101 11

Clinical features of Kawasaki disease (KD) display overlap with common pediatric viral illnesses, leading some to hypothesize that a viral infection is the inciting event for KD. To investigate viral infection history in KD patients, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitation sequencing assay covering the complete reference protein sequences of known viruses with human tropism. KD and matched febrile control sera did not demonstrate differe ...[more]

PMID: 32386318

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