Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.

ABSTRACT:

Background

Torque teno virus (TTV) is a ubiquitous non-pathogenic virus, which is suppressed in immunological healthy individuals but replicates in immune compromised patients. Thus, TTV load is a suitable biomarker for monitoring the immunosuppression also in lung transplant recipients. Since little is known about the changes of TTV load in lung cancer patients, we analyzed TTV plasma DNA levels in lung cancer patients and its perioperative changes after lung cancer surgery.

Material and methods

Patients with lung cancer and non-malignant nodules as control group were included prospectively. TTV DNA levels were measured by quantiative PCR using DNA isolated from patients plasma and correlated with routine circulating biomarkers and clinicopathological variables.

Results<

SUBMITTER: Stefani D 

PROVIDER: S-EPMC8171866 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature