Immunogenicity of replication-deficient vesicular stomatitis virus based rabies vaccine in mice.

ABSTRACT:

Background

Rabies is a viral disease that causes severe neurological manifestations both in humans and various mammals. Although inactivated and/or attenuated vaccines have been developed and widely used around the world, there are still concerns with regard to their safety, efficacy, and costs.

Objective

As demand has grown for a new rabies vaccine, we have developed a new vesicular stomatitis viruses (VSVs) based rabies vaccine that replaces glycoproteins with rabies virus (RABV) glycoprotein (GP), or so-called VSV/RABV-GP.

Methods

VSV/RABV-GP production was measured by sandwich ELISA. The generation of VSV/RABV-GP was evaluated with GP-specific antibodies and reduced transduction with GP-specific neutralizing antibodies. Virus entry was quantified by measuring the

SUBMITTER: Park JE 

PROVIDER: S-EPMC8172215 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature