High-Specific-Activity-¹³¹I-MIBG versus ¹⁷⁷Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma.

ABSTRACT: Targeted radionuclide therapies (TRT) using ¹³¹I-metaiodobenzylguanidine (¹³¹I-MIBG) and peptide receptor radionuclide therapy (¹⁷⁷Lu or ⁹⁰Y) represent several of the therapeutic options in the management of metastatic/inoperable pheochromocytoma/paraganglioma. Recently, high-specific-activity-¹³¹I-MIBG therapy was approved by the FDA and both ¹⁷⁷Lu-DOTATATE and ¹³¹I-MIBG therapy were recommended by the National Comprehensive Cancer Network guidelines for the treatment of metastatic pheochromocytoma/paraganglioma. However, a clinical dilemma often arises in the selection of TRT, especially when a patient can be treated with either type of therapy based on eligibility by MIBG and somatostatin receptor imaging. To a

SUBMITTER: Jha A 

PROVIDER: S-EPMC8172462 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature