Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease.

ABSTRACT: Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer's disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer's-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer's disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer's disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is

SUBMITTER: Pardilla-Delgado E 

PROVIDER: S-EPMC8172494 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature