The Effects of Lifetime Estrogen Exposure on Breast Epigenetic Age.

ABSTRACT:

Background

Estrogens are thought to contribute to breast cancer risk through cell cycling and accelerated breast aging. We hypothesize that lifetime estrogen exposure drives early epigenetic breast aging observed in healthy women. In this study, we examined associations between hormonal factors and epigenetic aging measures in healthy breast tissues.

Methods

We extracted DNA from breast tissue specimens from 192 healthy female donors to the Susan G. Komen Tissue Bank at the Indiana University Simon Cancer Center. Methylation experiments were performed using the Illumina EPIC 850K array platform. Age-adjusted regression models were used to examine for associations between factors related to estrogen exposure and five DNA methylation-based estimates: Grim age, pan-tissue age,

SUBMITTER: Sehl ME 

PROVIDER: S-EPMC8172523 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature