Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk.

ABSTRACT:

Background

Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.

Methods

Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.

Results

Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association

SUBMITTER: Brown DW 

PROVIDER: S-EPMC8172526 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature