High Chloride Burden and Clinical Outcomes in Critically Ill Patients With Large Hemispheric Infarction.

ABSTRACT: Background: In general, disease severity has been found to be associated with abnormal chloride levels in critically ill patients, but hyperchloremia is associated with mixed results regarding patient-centered clinical outcomes. We aimed to investigate the impact of maximum serum chloride concentration on the clinical outcomes of critically ill patients with large hemispheric infarction (LHI). Methods: We conducted a retrospective observational cohort study using prospective institutional neurocritical care registry data from 2013 to 2018. Patients with LHIs involving over two-thirds of middle cerebral artery territory, with or without infarction of other vascular territories, and a baseline National Institutes of Health Stroke Scale score of ≥13 were assessed. Those with a b

SUBMITTER: Gwak DS 

PROVIDER: S-EPMC8172791 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature