Setd4 controlled quiescent c-Kit⁺ cells contribute to cardiac neovascularization of capillaries beyond activation.

ABSTRACT: Blood vessels in the adult mammal exist in a highly organized and stable state. In the ischemic heart, limited expansion capacity of the myocardial vascular bed cannot satisfy demands for oxygen supply and the myocardium eventually undergoes irreversible damage. The predominant contribution of endogenous c-Kit⁺ cells is understood to be in the development and homeostasis of cardiac endothelial cells, which suggests potential for their targeting in treatments for cardiac ischemic injury. Quiescent cells in other tissues are known to contribute to the long-term maintenance of a cell pool, preserve proliferation capacity and, upon activation, facilitate tissue homeostasis and regeneration in response to tissue injury. Here, we present evidence of a Setd4-expressing quiescent c-Kit<

SUBMITTER: Xing S 

PROVIDER: S-EPMC8172824 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature