3D sub-nanometer analysis of glucose in an aqueous solution by cryo-atom probe tomography.

ABSTRACT: Atom Probe Tomography (APT) is currently a well-established technique to analyse the composition of solid materials including metals, semiconductors and ceramics with up to near-atomic resolution. Using an aqueous glucose solution, we now extended the technique to frozen solutions. While the mass signals of the common glucose fragments C_xH_y and C_xO_yH_z overlap with (H₂O)_nH from water, we achieved stoichiometrically correct values via signal deconvolution. Density functional theory (DFT) calculations were performed to investigate the stability of the detected pyranose fragments. This paper demonstrates APT's capabilities to achieve sub-nanometre resolution in tracing whole glucose molecules in a frozen solution by u

SUBMITTER: Schwarz TM 

PROVIDER: S-EPMC8172843 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature