Prognostic value of baseline interleukin 6 levels in liver decompensation and survival in HCC patients undergoing radioembolization.

ABSTRACT:

Background

To confirm the prognostic value of previously published baseline interleukin 6 (IL6) and IL8 cutoff values in survival and liver dysfunction in patients with advanced HCC undergoing ⁹⁰Y radioembolization.

Methods

A total of 83 patients (77 male) represented a subset of HCC patients undergoing ⁹⁰Y radioembolization combined with sorafenib as part of the prospective multicenter phase II trial SORAMIC. IL6 and IL8 levels were determined in serum samples collected at baseline. In this post hoc analysis, we sought to confirm the prognostic value of baseline cutoff values of 6.53 pg/mL and 60.8 pg/mL for IL6 and IL8, respectively, in overall survival (OS) or liver dysfunction (grade 2 bilirubin increase) after treatment.

Results

Median OS wa

SUBMITTER: Ocal O 

PROVIDER: S-EPMC8172845 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature