Transferrin-modified liposomes triggered with ultrasound to treat HeLa cells.

ABSTRACT: Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency of the encapsulated therapeutics. Upon reaching the tumor site, these liposomes can be triggered to release their content in a controlled manner using ultrasound (US). In this study, drug release from pegylated calcein-loaded liposomes modified with transferrin (Tf) and triggered with US was evaluated. Low-frequency ultrasound at 20-kHz using three different power densities (6.2 mW/cm², 9 mW/cm² and 10 mW/cm²) was found to increase calcein release. In addition, transferrin-conjugated pegylated liposomes (Tf-PEG liposomes) were found to

SUBMITTER: AlSawaftah NM 

PROVIDER: S-EPMC8172941 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature