Construction of Condition-Specific Gene Regulatory Network Using Kernel Canonical Correlation Analysis.

ABSTRACT: Gene expression profile or transcriptome can represent cellular states, thus understanding gene regulation mechanisms can help understand how cells respond to external stress. Interaction between transcription factor (TF) and target gene (TG) is one of the representative regulatory mechanisms in cells. In this paper, we present a novel computational method to construct condition-specific transcriptional networks from transcriptome data. Regulatory interaction between TFs and TGs is very complex, specifically multiple-to-multiple relations. Experimental data from TF Chromatin Immunoprecipitation sequencing is useful but produces one-to-multiple relations between TF and TGs. On the other hand, co-expression networks of genes can be useful for constructing condition transcriptional networks,

SUBMITTER: Jeong D 

PROVIDER: S-EPMC8172963 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature