Engineered reproductively isolated species drive reversible population replacement.
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ABSTRACT:
SUBMITTER: Buchman A
PROVIDER: S-EPMC8173020 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Engineered reproductively isolated species drive reversible population replacement.
Buchman Anna A Shriner Isaiah I Yang Ting T Liu Junru J Antoshechkin Igor I Marshall John M JM Perry Michael W MW Akbari Omar S OS
Nature communications 20210602 1
Engineered reproductive species barriers are useful for impeding gene flow and driving desirable genes into wild populations in a reversible threshold-dependent manner. However, methods to generate synthetic barriers are lacking in advanced eukaryotes. Here, to overcome this challenge, we engineer SPECIES (Synthetic Postzygotic barriers Exploiting CRISPR-based Incompatibilities for Engineering Species), an engineered genetic incompatibility approach, to generate postzygotic reproductive barriers ...[more]
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