Safranal Alleviated OVA-Induced Asthma Model and Inhibits Mast Cell Activation.

ABSTRACT:

Introduction

Asthma is a chronic and recurring airway disease, which related to mast cell activation. Many compounds derived from Chinese herbal medicine has promising effects on stabilizing mast cells and decreasing inflammatory mediator production. Safranal, one of the active compounds from Crocus sativus, shows many anti-inflammatory properties. In this study, we evaluated the effect of safranal in ovalbumin (OVA)-induced asthma model. Furthermore, we investigate the effectiveness of safranal on stabilizing mast cell and inhibiting the production of inflammatory mediators in passive systemic anaphylaxis (PSA) model.

Methods

OVA-induced asthma and PSA model were used to evaluate the effect of safranal in vivo. Lung tissues were collected for H&E, TB, IHC, and

SUBMITTER: Lertnimitphun P 

PROVIDER: S-EPMC8173045 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature