HLA Desensitization in Solid Organ Transplantation: Anti-CD38 to Across the Immunological Barriers.

ABSTRACT: The presence of anti-human leucocyte antigen (HLA) antibodies in the potential solid organ transplant recipient's blood is one of the main barriers to access to a transplantation. The HLA sensitization is associated with longer waitlist time, antibody mediated rejection and transplant lost leading to increased recipient's morbidity and mortality. However, solid organ transplantation across the HLA immunological barriers have been reported in recipients who were highly sensitized to HLA using desensitization protocols. These desensitization regimens are focused on the reduction of circulating HLA antibodies. Despite those strategies improve rates of transplantation, it remains several limitations including persistent high rejection rate and worse long-term outcomes when compare with non-sen

SUBMITTER: Joher N 

PROVIDER: S-EPMC8173048 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature