Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.

ABSTRACT: Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possibility that these genes may influence AD non-linearly, through interactions of their products. In this paper, we selected two stress-related genes (GCN2/EIF2AK4 and APP) based on recent findings from experimental studies which suggest that the interplay between these genes might influence AD in humans. To test this hypothesis, we evaluated the effects of interactions between SNPs in these two genes on AD occurrence, using the Health and Retirement Study data on white indidividuals. We found several interacting SNP-pairs whose associations

SUBMITTER: Yashin AI 

PROVIDER: S-EPMC8173104 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature