Do gene expression findings from mouse models of cocaine use recapitulate human cocaine use disorder in reward circuitry?

ABSTRACT: Animal models of drug use have investigated possible mechanisms governing human substance use traits for over 100 years. Most cross-species research on drug use/addiction examines behavioral overlap, but studies assessing neuromolecular (e.g. RNA) correspondence are lacking. Our study utilized transcriptome-wide data from the hippocampus and ventral tegmental area (VTA)/midbrain from a total of 35 human males with cocaine use disorder/controls and 49 male C57BL/6J cocaine/saline administering/exposed mice. We hypothesized differential expressed genes and systems of co-expressed genes (gene networks) would show appreciable overlap across mouse cocaine self-administration and human cocaine use disorder. We found modest, but significant relationships between differentially expressed genes ass

SUBMITTER: Huggett SB 

PROVIDER: S-EPMC8173322 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature