Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology.

ABSTRACT:

Background

The coronavirus disease 2019 (COVID-19), a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide, was described to be frequently accompanied by extrapulmonary manifestations, including liver dysfunction. Liver dysfunction and elevated liver enzymes were observed in about 53% of COVID-19 patients.

Aim

To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver dysfunction.

Methods

The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was analyzed. Differentially expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and pathways. The differential

SUBMITTER: Hammoudeh SM 

PROVIDER: S-EPMC8173390 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature