Genetic Variants Associated With Unexplained Sudden Cardiac Death in Adult White and African American Individuals.

ABSTRACT:

Importance

Unexplained sudden cardiac death (SCD) describes SCD with no cause identified. Genetic testing helps to diagnose inherited cardiac diseases in unexplained SCD; however, the associations between pathogenic or likely pathogenic (P/LP) variants of inherited cardiomyopathies (CMs) and arrhythmia syndromes and the risk of unexplained SCD in both White and African American adults living the United States has never been systematically examined.

Objective

To investigate cases of unexplained SCD to determine the frequency of P/LP genetic variants of inherited CMs and arrhythmia syndromes.

Design, setting, and participants

This genetic association study included 683 African American and White adults who died of unexplained SCD and were included in an autopsy registry

SUBMITTER: Guo L 

PROVIDER: S-EPMC8173469 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature