Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions.

ABSTRACT: Carbohydrates (glycans, saccharides, and sugars) are essential molecules in all domains of life. Research on glycoscience spans from chemistry to biomedicine, including material science and biotechnology. Access to pure and well-defined complex glycans using synthetic methods depends on the success of the employed glycosylation reaction. In most cases, the mechanism of the glycosylation reaction is believed to involve the oxocarbenium ion. Understanding the structure, conformation, reactivity, and interactions of this glycosyl cation is essential to predict the outcome of the reaction. In this Account, building on our contributions on this topic, we discuss the theoretical and experimental approaches that have been employed to decipher the key features of glycosyl cations, from their struc

SUBMITTER: Franconetti A 

PROVIDER: S-EPMC8173606 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature