Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition.

ABSTRACT: The microtubule-associated protein tau promotes the stabilization of the axonal cytoskeleton in neurons. In several neurodegenerative diseases, such as Alzheimer's disease, tau has been found to dissociate from microtubules, leading to the formation of pathological aggregates that display an amyloid fibril-like structure. Recent structural studies have shown that the tau filaments isolated from different neurodegenerative disorders have structurally distinct fibril cores that are specific to the disease. These "strains" of tau fibrils appear to propagate between neurons in a prion-like fashion that maintains their initial template structure. In addition, the strains isolated from diseased tissue appear to have structures that are different from those made by the most commonly used in vi

SUBMITTER: Ingham DJ 

PROVIDER: S-EPMC8173610 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature