Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval.

ABSTRACT: Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules with high potency and significant toxicity were encapsulated in polymeric micelles. Polymeric micelles have shown improved pharmacokinetic profiles in preclinical animal models and enhanced efficacy with a superior safety profile for therapeutic drugs. Several polymeric micelle formulations have reached the clinical stage and are either in clinical trials or are approved for human use. This furthers interest in this field and underscores the need for additional learning of how to best design and apply these micellar carriers to improve the clinical outcomes of many drugs. In this review, we provide detailed informa

SUBMITTER: Hwang D 

PROVIDER: S-EPMC8173698 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature