Recovery from impaired working memory performance during chronic Δ-9-tetrahydrocannabinol administration to adolescent rhesus monkeys.

ABSTRACT:

Background

The relationship between adolescent cannabis use and susceptibility to persistent cognitive impairments is poorly understood.

Aims

We examined the effects of repeated exposure to Δ-9-tetrahydrocannabinol (THC) on reinforcement-related learning and performance of spatial working memory (WM) tasks of varying difficulty in adolescent monkeys.

Methods

Seven pairs of male adolescent rhesus monkeys, matched for baseline cognitive performance, received vehicle or THC intravenously 5 days/week for 12 months. Performance on 4-item spatial WM trials was assessed throughout the 12-month study period. At the 6-month time point, more difficult novel and distractor 8-item spatial WM trials were added. Residual effects on performance were determined 23 or 71 h after THC o

SUBMITTER: Verrico CD 

PROVIDER: S-EPMC8173701 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature